Recurrent severe cutaneous reaction to fluoroquinolones and rifampicin in a human immunodeficiency virus-positive patient with disseminated tuberculosis: A rare case report.

Authors

Divya Chamariya, Taru Garg, Hitesh Verma, Lalit Kumar Gupta

Published in

Indian journal of pharmacology. Volume 58. Issue 5. Pages 593-596. Sep 01, 2026. Epub Sep 02, 2026.

Abstract

We report a 47-year-old human immunodeficiency virus-positive male with disseminated tuberculosis who developed recurrent maculopapular eruptions with mucosal involvement following exposure to multiple drugs, including diclofenac, rifampicin, and fluoroquinolones. Sequential drug rechallenge strongly implicated fluoroquinolones and rifampicin. He was successfully managed with systemic corticosteroids, intravenous immunoglobulin, and careful sequential reintroduction of nonculprit anti-tubercular therapy drugs. This case highlights the importance of drug reintroduction and cautious use of fluoroquinolones and rifampicin in immunocompromised patients.

PMID:
42683992
Bibliographic data and abstract were imported from PubMed on 02 Sep 2026.

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