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A world view: Considerations of sociocultural diversity in the study of subjective cognitive decline in Alzheimer's disease and related dementias.

Created on 02 Sep 2026

Authors

Mark A Dubbelman, Tanisha G Hill-Jarrett, Silvia Chapman, Gustavo Alves Andrade Dos Santos, Martina Azar, Ganesh M Babulal, Tyler R Bell, Mark A Bernard, Carolina Boza-Calvo, Anthony Q Briggs, Omonigho Michael Bubu, Heather E Cuevas, N Maritza Dowling, Darlingtina K Esiaka, Bernadette A Fausto, Fabricio Ferreira de Oliveira, Carol E Franz, Joyla A Furlano, Christopher Gonzalez-Corona, M Aaron Guest, Veer Bala Gupta, Vivek K Gupta, Daija Jackson, Jillian L Joyce, Michael R Kann, William S Kremen, Athene Lee, Jairo E Martinez, Arjun V Masurkar, Maia A McLin, Elisa de Paula França Resende, Zahra Rahemi, Brianca C Renfro, Márlon Juliano Romero Aliberti, Shaina Shagalow, Andrea Slachevsky, Juliana N De Souza Talarico, Jean François Trani, Carol Van Hulle, Leah Waltrip, Stephen Ojiambo Wandera, Charles C Windon, Mônica Sanches Yassuda, Davide V Moretti, Elizabeth Kuhn, Elke Butterbrod, Katherine A Gifford, Sietske A M Sikkes, Raphael M Castilhos, Rachel Nosheny, Shana D Stites, a collaboration of the Alzheimer's Association International Society to Advance Alzheimer's Research and Therapy Subjective Cognitive Decline and Diversity and Disparities Professional Interest Areas

Published in

Alzheimer's & dementia : the journal of the Alzheimer's Association. Volume 22. Issue 9. Pages e71779.

Abstract

Subjective cognitive decline (SCD) refers to cognitive concerns that may occur with or without objective impairment on standardized testing. Studies suggest that SCD may be an early clinical marker of Alzheimer's disease and related dementias, and that it can predict future objective cognitive decline and progression to dementia. However, the research that supports these conclusions is primarily based on samples with homogeneous socioeconomic and cultural backgrounds. The limited studies in samples with more diverse representations of racial, ethnic, gender, and sexual orientation characteristics show varying SCD prevalence, correlates, and outcomes. Here, we review this literature, focusing on how to apply the findings to advance our understanding of SCD. We further evaluate how our findings inform a roadmap for future research. Overall, we conclude that broader investigations across more diverse populations enhance our understanding of the factors that may differentially contribute to SCD and shape its utility as a clinical metric.

PMID:
42683545
Bibliographic data and abstract were imported from PubMed on 02 Sep 2026.

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