Phenolic compounds from Coreopsis tinctoria Nutt. and their anti-inflammatory activity.

Authors

Dilinare Abdurehman, Yindengzhi Guoruoluo, Jun Li, Xueying Lu, Geyu Liu, Haji Akber Aisa

Published in

Phytochemistry. Pages 115077. Sep 02, 2026. Epub Sep 02, 2026.

Abstract

Coreopsis tinctoria Nutt., a traditional edible and medicinal plant, is recognized for its bioactive compounds with potential health benefits. In this study, eight previously unreported compounds including a biflavone (1), an acylated flavonol glycoside (2), an acylated aurone glycoside (3), five phenolic bisabolane-type sesquiterpenoids (4-8), along with nine known compounds, were isolated and structurally elucidated using NMR, HRESIMS, ECD, and quantum chemical calculations. Compounds 7 and 9 showed moderate inhibition of nitric oxide production in LPS-induced RAW 264.7 cells, with IC₅₀ values of 24.56 ± 0.62 μM and 17.72 ± 0.53 μM, respectively. In the ELISA assays, compound 9 reduced the production of pro-inflammatory cytokines, including TNF-α and IL-6. Network pharmacology and molecular docking analyses revealed that compound 9 exerted anti-inflammatory effects via multiple pathways, and exhibited high binding affinity for potential key targets associated with anti-inflammatory activity. Furthermore, molecular dynamics simulations confirmed the stability of those complexes. These findings provide preliminary evidence for the potential of bisabolane-type sesquiterpenoids as lead compounds for developing anti-inflammatory ingredients.

PMID:
42686048
Bibliographic data and abstract were imported from PubMed on 03 Sep 2026.

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