Post-Sepsis Syndrome after Critical Illness: Epidemiology and Long-term Outcomes.

Authors

Hannah Wozniak, Eleonora Balzani, Erminio Santangelo, Margaret Herridge

Published in

Critical care clinics. Volume 42. Issue 4. Pages 683-700. Epub Jun 22, 2026.

Abstract

Survival after sepsis has improved over recent decades, resulting in a growing population of sepsis survivors. Survivorship after sepsis is frequently marked by significant long-term morbidity, including new functional dependence, cognitive impairment, anxiety, depression, post-traumatic stress symptoms, recurrent hospitalization, and excess long-term mortality. This article presents the current knowledge on the epidemiology of long-term outcomes among critically ill adult sepsis survivors, with particular emphasis on patient-centered outcomes, their prevalence, and contributing factors, and a discussion of the emerging role of biomarkers, immunologic profiling, and artificial intelligence in individualized prediction and post-sepsis care pathways.

PMID:
42686292
Bibliographic data and abstract were imported from PubMed on 03 Sep 2026.

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