Real-time Subgrouping of Sepsis and Systemic Inflammatory Syndromes.

Authors

Ross McMullan, Sivasubramanium V Bhavani, Pratik Sinha

Published in

Critical care clinics. Volume 42. Issue 4. Pages 839-855. Epub Jun 22, 2026.

Abstract

Biological heterogeneity in sepsis and related systemic inflammatory syndromes has constrained therapeutic advancement and reduced the efficiency of conventional trial designs. Reproducible host response-derived sepsis subgroups recur across clinical, protein biomarker-based, and transcriptomic dimensions. A practical route to the implementation and evaluation of real-time subgrouping is a 2-stage pipeline that combines assessment of sepsis subgroup eligibility with subsequent classification. Priorities for future work are embedding classifiers and diagnostic platforms with high validity into clinical workflow so that prospective clinical trials can test their clinical utility.

PMID:
42686300
Bibliographic data and abstract were imported from PubMed on 03 Sep 2026.

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