Early Management of Sepsis.

Authors

Elizabeth S Munroe, Ithan D Peltan, Hallie C Prescott

Published in

Critical care clinics. Volume 42. Issue 4. Pages 719-743. Epub Jun 12, 2026.

Abstract

Prompt recognition and appropriate early management of sepsis reduces mortality. There are 2 major goals of early sepsis management, which should be pursued urgently and in parallel-(1) infection control and (2) hemodynamic resuscitation. Treating infection involves timely antimicrobial therapy, and for some infections, source control. Hemodynamic resuscitation should start with a rapid bolus of balanced crystalloid followed by personalized approaches that tailor fluid and vasopressor therapy to evolving patient physiology. In patients who do not improve with initial antibiotic therapy and resuscitation, it is essential to reassess adequacy of infection control and resuscitation.

PMID:
42686294
Bibliographic data and abstract were imported from PubMed on 03 Sep 2026.

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