Exploring interneuron conduction time in the motor cortex and the link to motor function in individuals with chronic stroke.

Authors

A Rajendran, R Denyer, C Rubino, J L Neva, L A Boyd

Published in

Journal of neurophysiology. Sep 02, 2026. Epub Sep 02, 2026.

Abstract

Interneurons in the motor cortex (M1) contribute to key motor functions, which are often altered after stroke. Changing the direction of transcranial magnetic stimulation (TMS) alters the onset time of motor evoked potentials (MEP). Yet, how stroke changes motor evoked potential (MEP) onset latency in association with directional TMS is not understood. The goals of the current study were to: 1) investigate directional MEP onset in the contralesional and ipsilesional hemispheres, and 2) characterize the relationship between MEP onset latency and motor function post-stroke. Twenty individuals with chronic stroke received single pulse, monophasic TMS over M1 in the lateral-medial (LM), posterior-anterior (PA), and anterior-posterior (AP) directions. Latency of activation of the corticospinal tract was indexed by subtracting MEP onset times from the paretic and non-paretic Extensor Carpi Radialis (ECR) muscle in the LM direction from the AP and PA directions in both hemispheres. Upper limb motor function in was quantified using the Wolf-Motor Function Test (WMFT). There was a significant difference between AP-LM and PA-LM MEP onset latencies within and between hemispheres. AP-LM MEP onset latency was longer in the contralesional as compared to the ipsilesional hemisphere. Hemispheric differences in AP-LM MEP onset latency explained a significant proportion of variance in WMFT performance between limbs. AP-LM MEP onset latency is post-stroke and larger hemispheric imbalances in AP-LM MEP onset times related to worse motor function. These data highlight a new relationship between connectivity of interneuron pools in the human motor cortex and motor function after stroke.

PMID:
42686217
Bibliographic data and abstract were imported from PubMed on 03 Sep 2026.

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