[Antinuclear and antinucleoprotein antibodies Laboratory and clinical aspects].

Authors

Dehlia Chevalley, Camillo Ribi, Maxime Ringwald

Published in

Revue medicale suisse. Volume 22. Issue 973. Pages 1417-1422. Sep 02, 2026.

Abstract

Autoimmune diseases result from a breakdown of immune tolerance, which can precede clinical manifestations by several years. Screening for antinuclear antibodies (ANA) is commonly performed in patients with nonspecific symptoms suggestive of a systemic autoimmune disease. In the absence of a compatible clinical context, detecting autoantibodies can cause confusion and concern. This article provides an integrated clinicobiological analysis of ANA and extractable nuclear antigen testing, emphasizing the importance of rigorous assay validation and contextualized interpretation to prevent overdiagnosis and unnecessary investigations.

PMID:
42687730
Bibliographic data and abstract were imported from PubMed on 03 Sep 2026.

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