Adaptation of the Yield-Scaling Factor to Reduce Target Yield Deviation and Donation Time in Pathogen-Reduced Apheresis Platelet Collections Using the Sysmex XN1000 Blood Bank Mode.

Authors

Marco Amato, Anita Siller, Lisa Seekircher, Manfred Astl, Lena Tschiderer, Peter Willeit, Harald Schennach

Published in

Annals of laboratory medicine. Sep 03, 2026. Epub Sep 03, 2026.

Abstract

Platelet concentrates from apheresis donations are indispensable in transfusion medicine. Integration of pathogen reduction (PR) technologies into platelet manufacturing requires adjustment of apheresis devices to ensure consistent platelet yields while minimizing donation time. We investigated the suitability of Sysmex XN1000 (Sysmex Corporation, Kobe, Japan) in blood bank mode (BBM) for measuring platelet concentrates to optimize the yield-scaling factor (YSF) of apheresis devices, thereby standardizing target yields and reducing donation time.
We compared measurements with the Sysmex XN530 and XN1000 BBM and evaluated three Trima Accel (Terumo, Tokyo, Japan) YSF setups (YSF 0.90/XN530, YSF 0.90/XN1000, and YSF 1.05/XN1000). Differences in yield deviation and donation time were assessed using linear mixed-effects models adjusted for target yield with robust SEs.
We analyzed 4,383 platelet apheresis procedures from 1,573 donors across setups in large-volume (LV) and dual-storage (DS) collections. Compared with YSF 0.90/XN530, YSF 0.90/XN1000 and YSF 1.05/XN1000 significantly reduced yield deviation by 0.26 and 0.41×10¹¹ platelets/unit (95% confidence interval [CI] 0.18-0.34 and 0.35-0.48, respectively) in LV collections and by 0.34 and 0.24×10¹¹ platelets/unit (95% CI 0.24-0.45 and 0.01-0.47, respectively) in DS collections. Compared with YSF 0.90/XN530, YSF 1.05/XN1000 reduced the donation time by 8.09 min (6.93-9.26) and 9.88 min (6.81-12.94) for LV and DS collections, respectively.
YSF 0.90/XN1000 and YSF 1.05/XN1000 reduced yield deviation and donation time than did YSF 0.90/XN530, supporting the use of XN1000 BBM to calibrate Trima Accel apheresis devices and can help in standardizing target yields while reducing donation time in PR.

PMID:
42687495
Bibliographic data and abstract were imported from PubMed on 03 Sep 2026.

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