Marantic endocarditis: a multidisciplinary case in which the etymology helps to determine the aetiology.

Authors

Stefano Di Gregorio, Unal Tokkuzun, Angelo Di Simone, Andrea Menafoglio, Andrea Demarchi

Published in

European heart journal. Case reports. Volume 10. Issue 9. Pages ytag112. Epub Feb 13, 2026.

Abstract

Non-bacterial thrombotic endocarditis (NBTE), also known as 'Marantic' endocarditis, is a rare and life-threatening condition that involves thrombotic thickening of cardiac structures, most often heart valves, with the potential to cause multiple embolisms. In the literature, NBTE has been reported in association with advanced malignancies, connective tissue disease, and inflammatory disorders. We present a case of marantic endocarditis (ME) related to acute promyelocytic leukaemia (APL) causing visceral organ infarction, notably splenic, renal, and brain, without the development of major sequelae.
We report a case of a 43-year-old male with a history of bicuspid aortic valve and aortic coarctation, surgically corrected at an early age, was presented to our service showing signs of deep vein thrombosis, disseminated intravascular coagulation (DIC), and multiple signs of embolism. During diagnostic evaluation, a non-bacterial thrombotic vegetation was identified on the aortic valve, and an early relapse of APL was confirmed. The patient was treated with a standard regimen for APL and anticoagulation therapy. On close follow-up, we observed a reduction in the size of the vegetation without structural cardiac damage and further signs of thromboembolism.
As highlighted, in the emerging literature, the presence of multiple systemic emboli, whether cutaneous or involving visceral organs, should prompt clinicians to evaluate for endocarditis and distinguish between infective and non-infective causes. This is particularly essential in setting of malignancy or systemic inflammatory state. The present case underscores the importance of the timely recognition of ME in all cases presenting with DIC, in order to prevent further escalation. In addition, it offers an opportunity to reinforce the understanding of pathophysiological mechanisms and open the window for new insights and further reflections.

PMID:
42689303
Bibliographic data and abstract were imported from PubMed on 03 Sep 2026.

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