Five New Iridoids From the Leaves of Viburnum macrocephalum f. macrocephalum and Their Free Radical Scavenging Activity.

Authors

Ya-Jiao Chen, Hong-Juan Zhou, Jia Chen, Jian-Hua Shao, Chun-Chao Zhao

Published in

Chemistry & biodiversity. Volume 23. Issue 9. Pages e71649.

Abstract

An investigation of the chemical constituents of Viburnum macrocephalum f. macrocephalum leaves (VMML) resulted in the purification of five previously unreported iridoids, viburetins D-H (1-5), along with one known analogue (6). Compounds 1-5 were identified by combined spectroscopic and spectrometric techniques, including 1D/2D NMR, HRESIMS, and ECD. Antioxidant assays revealed that compounds 2, 5, and 6 exhibited DPPH (IC₅₀: 36.58-53.90 µM) and ABTS (IC₅₀: 25.96-45.80 µM) free radical scavenging activity, whereas compound 1 was appreciably active in the ABTS assay (IC₅₀ = 58.47 µM). Notably, compound 6 was the most potent antioxidant, showing greater activity than the positive control Trolox in both assays (DPPH: IC₅₀ = 36.58 vs. 41.12 µM; ABTS: IC₅₀ = 25.96 vs. 29.09 µM). These findings have enriched the chemical diversity of iridoids from VMML and provided preliminary evidence for their free radical scavenging activity.

PMID:
42689421
Bibliographic data and abstract were imported from PubMed on 03 Sep 2026.

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