Anti-inflammatory Diterpenoids and Sesquiterpenoids from the Rhizomes of Shell Ginger (Alpinia zerumbet).

Authors

Jinghui Wu, Xinyue Liu, Juheng Wu, Ruyang Guan, Ying Lu, Jun Ouyang, Jingwen Xu, Yihai Wang, Xiangjiu He

Published in

Journal of agricultural and food chemistry. Volume 74. Issue 34. Pages 27138-27156. Sep 02, 2026.

Abstract

Shell ginger (Alpinia zerumbet) is a perennial species widely utilized as both an edible spice and a medicinal plant. Phytochemical investigation of its rhizomes yielded 33 terpenoids, of which 12 are previously undescribed compounds, comprising both diterpenes and sesquiterpenes. Notably, compound 1 represents a rare, highly oxygenated isospongiane-type diterpenoid with a novel skeleton. The anti-inflammatory potential of all isolates was assessed using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and BV2 microglial cells. Subsequent mechanism-oriented assays demonstrated that compounds 2 and 4 attenuated neuroinflammation in BV2 cells through an effect attributable to inhibition of nuclear factor kappa-B (NF-κB) nuclear translocation, reduction of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and signal transducer and activator of transcription 3 (STAT3) protein expression, and downregulation of the mRNA levels of iNOS, interleukin-1β (IL-1β), COX-2, and tumor necrosis factor-α (TNF-α).

PMID:
42690793
Bibliographic data and abstract were imported from PubMed on 04 Sep 2026.

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