Hiring in life sciences? Share your open positions with our professional community. Read more Close

Advertisement

Deceptive bias measurement in deep learning: Assessing shortcut reliance in TCGA cancer models.

Created on 04 Sep 2026

Authors

Farnaz Kheiri, Shahryar Rahnamayan, Masoud Makrehchi

Published in

PLOS digital health. Volume 5. Issue 9. Pages e0001165. Epub Sep 03, 2026.

Abstract

Machine learning bias is a persistent challenge because it can create unfair outcomes, limit generalization, and reduce trust in real-world applications. A key source of this problem is shortcut learning, where models exploit signals linked to sensitive attributes, such as the data source or collection site, instead of relying on task-relevant features. To address this, we propose the Deceptive Signal metric, a novel quantitative measure designed to assess the extent of a model's reliance on hidden shortcuts during the learning process. This metric is derived via the Deceptive Bias Detection pipeline, which isolates shortcut dependence by contrasting the model's behavior under two controlled conditions: (1) Full Exclusion, where a sensitive subgroup is completely removed from training; and (2) Partial Exclusion, where the model has limited access to specific classes within that subgroup. By calculating the behavioral shift between these settings, the Deceptive Signal metric provides a quantitative estimate of the model's susceptibility to learning task-irrelevant patterns. In experiments with the TCGA histopathology dataset, our metric successfully quantified substantial dependencies on center-specific artifacts in models trained for cancer classification.

PMID:
42691130
Bibliographic data and abstract were imported from PubMed on 04 Sep 2026.

Read full publication at:
Please sign in to see all details.

Advertisement

Stats

  • Community rating n/a 0 votes
  • Reviewers' rating n/a 0 votes
  • Your rating

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

  • Recommendations n/a n/a positive of 0 vote(s)
  • Views 5
  • Comments 0

Recommended by

  • No recommendations yet.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.

Advertisement