Authors
Wei Wang, Shreyans Chatterjee, Qi Lu, Kaifa Xin, Priyadharshini Balasubramanian, Fedor Jelezko, Jan Münch, Lei Liu, Rüdiger Groß, Yingke Wu, Tanja Weil
Published in
Nano letters. Volume 26. Issue 34. Pages 11288-11295. Sep 02, 2026.
Abstract
Compact and ultrasensitive detection of viral RNA and cancer-associated biomarkers is essential for early diagnosis and disease management. Conventional lateral flow assays (LFA), however, often lack the sensitivity and quantitative reliability required for low-abundance nucleic acids in complex matrices without amplification. Here, we present a quantum-enabled, magnetically modulated fluorescent nanodiamond LFA (FND-LFA) for amplification-free RNA detection through nucleic acid hybridization. Fluorescent nanodiamonds provide photostable, spin-dependent fluorescence, while magnetic modulation separates target-associated signals from background. Pixel-wise contrast analysis with Gaussian modeling enables robust quantitative readout, and sequence-optimized probes selectively hybridize to low-secondary-structure RNA regions without denaturation. The platform achieves a 10 fM detection limit and a linear range of 10 fM to 10 pM for SARS-CoV-2 RNA, together with a 100 fM detection limit for cancer-associated miRNAs. This strategy offers a compact and generalizable route for sensitive, amplification-free RNA diagnostics.
PMID:
42690796
Bibliographic data and abstract were imported from PubMed on 04 Sep 2026.
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