Mechanisms of sulbactam-durlobactam resistance in Acinetobacter baumannii.

Authors

Yu Feng, Laurent Poirel, Zhiyong Zong

Published in

Trends in microbiology. Sep 03, 2026. Epub Sep 03, 2026.

Abstract

Sulbactam-durlobactam is the first-line agent against carbapenem-resistant Acinetobacter baumannii. Resistance can be conferred by metallo-β-lactamases alone or penicillin-binding protein 3 alterations plus β-lactamase overproduction or enhanced efflux. Other reported mechanisms remain associative and resistance in guideline-recommended carbapenem addition is unclear, underscoring the need for mechanistic validation and further studies.

PMID:
42692862
Bibliographic data and abstract were imported from PubMed on 04 Sep 2026.

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