[Secondary metabolites of endophytic fungus Penicillium sp. L01 from Consolida rugulosa and their in vitro antimicrobial activities].

Authors

Fei Lyu, Xiao-Qiang Zhu, Liang Lei, Xiao-Bin Bi, Rong Fang

Published in

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. Volume 51. Issue 16. Pages 4666-4672.

Abstract

This study aimed to investigate the secondary metabolites of the endophytic fungus Penicillium sp. L01 isolated from Consolida rugulosa and their antimicrobial activities. Five compounds were isolated from the ethyl acetate layer of the rice fermentation products of Penicillium sp. L01 by normal-phase silica gel, Sephadex LH-20, and ODS column chromatography and high performance liquid chromatography(HPLC). Their structures were identified as penifuranone A(1), penifattacid A(2), huaspenone B(3), psiAα(4), and N-linoleoylethanolamine(5). Compounds 1 and 2 were new compounds, and compounds 4 and 5 were isolated from Penicillium for the first time. In addition, all compounds were screened for in vitro antimicrobial activity by using a two-fold dilution method. The antimicrobial activity tests showed that compounds 1 and 3 significantly inhibited methicillin-resistant Staphylococcus aureus(MRSA) with minimal inhibitory concentration(MIC) of 16.0 and 8.0 μg·mL~(-1), respectively.

PMID:
42693019
Bibliographic data and abstract were imported from PubMed on 04 Sep 2026.

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