Nickel/Photoredox-Catalyzed Dicarbofunctionalization of Alkenes via Ketone C─C Bond Cleavage: Access to an Enantioselective Variant.

Authors

Chenglin Peng, Yahui Jia, Tu Anh Tran, Qianqian Zhai, Shuai Liu, Craig S Day, Liang Xu

Published in

Angewandte Chemie (International ed. in English). Pages e2368387. Sep 04, 2026. Epub Sep 04, 2026.

Abstract

In this study, we disclose a general protocol for the three-component difunctionalization of alkenes using nickel catalysis and aliphatic carbonyl precursors that are activated by sp³ C─C bond cleavage. Under visible-light irradiation, this transformation provides an efficient strategy to install two vicinal carbon─carbon bonds across alkenes from easily accessible precursors. Notably, the alkene difunctionalization was extended to an enantioselective variant, providing streamlined access to complex enantioenriched scaffolds. The reaction exhibits operational simplicity, broad substrate scope, and excellent regioselectivity and chemoselectivity while demonstrating compatibility with bioactive motifs and the ability to expedite the synthesis of pharmaceutically relevant molecules.

PMID:
42694015
Bibliographic data and abstract were imported from PubMed on 04 Sep 2026.

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