Revisiting the impact on mortality of intravenous iron administration during acute inpatient infections.

Authors

Richard Wu, Yu Rim Park, Lyndon P James, Omar El-Fadel, Nicholas A Bosch

Published in

Journal of hospital medicine. Sep 04, 2026. Epub Sep 04, 2026.

Abstract

The safety of iron repletion during acute infections has long been debated. A recent retrospective analysis reported significant and rapid mortality benefits from inpatient iron infusions given to patients with acute infections. This potential paradigm shift in inpatient management of iron deficiency anemia puts into question whether current common practice of withholding iron during infections is not only unnecessary, but actively harming patients. Our analysis utilizing the same database but with adjustments for additional confounders largely identified no difference in mortality in hospitalized patients with iron deficiency anemia who survived at least 7 days after being admitted for an infection, and suggests further studies are needed to truly clarify the safety and role for intravenous iron during acute infections.

PMID:
42693818
Bibliographic data and abstract were imported from PubMed on 04 Sep 2026.

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