Authors
Linda Beer, Stacy M Crim, Yunfeng Tie, Jesse O'Shea, Jason A Craw, Eve Koehler, Kate Buchacz, Joseph Prejean
Published in
Journal of acquired immune deficiency syndromes (1999). Sep 04, 2026. Epub Sep 04, 2026.
Abstract
Long-acting injectable antiretroviral therapy (LA-ART) has enormous potential benefit for increasing viral suppression among persons with HIV (PWH).
U.S. HIV care facilities.
We analyzed data on past 12-month LA-ART prescriptions collected over 3 annual data collection cycles (2021-2023) from probability samples of U.S. adults with HIV (collected 6/1/2021-5/30/2024, N=11,524). We report weighted percentages of PWH prescribed LA-ART and use prevalence ratios (PRs) with predicted marginal means and 95% confidence intervals (CIs) to quantify differences in prescription of LA-ART over time and between groups.
The percentage of PWH prescribed LA-ART increased from 0.4% (CI 0.2-0.7) in the 2021 cycle to 3.4% (CI 2.8-3.9) in the 2023 cycle (PR 7.8 [CI 4.5-13.6]). During the 2022-2023 cycles, prescription of LA-ART was higher among those living in Northeastern Medical Monitoring Project (MMP) states versus Southern MMP states (3.4% [CI 2.4-4.3] vs. 1.9% [CI 1.3-2.5], PR 1.8 [1.2-2.8]) and those receiving care at Ryan White HIV/AIDS program (RWHAP)-funded versus non-funded facilities (2.9% [CI 2.4-3.4] vs. 1.8% [CI 1.3-2.4], PR 1.6 [CI 1.1-2.2]). Older age (>50 vs. <40 years) was also associated with lower ART prescription.
Prescription of LA-ART is increasing among U.S. adults with HIV, though prevalence remains low. LA-ART uptake lagged in the South, where HIV infections and negative health outcomes are disproportionately high. Comprehensive HIV care delivery-such as found in RWHAP-facilities-may facilitate LA-ART adoption.
PMID:
42696712
Bibliographic data and abstract were imported from PubMed on 05 Sep 2026.
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