Epidermolysis Bullosa Simplex-Severe Caused by KRT5 p.Glu477Lys: Challenges Encountered in This High-Risk Subtype.

Authors

Nataliia Zhovta, Joana Lanz, Bettina Hafner, Karin Willi, Sven-Eric Baller, Stephanie Adzikah, Martin Theiler, Lisa Weibel, Isabelle Luchsinger, Kathrin Neuhaus, Simon Küpper, Christa Relly, Jörg Thomas, Eva Bergsträsser, Nicole Knöpfel, Agnes Schwieger-Briel

Published in

Pediatric dermatology. Volume 43 Suppl 2. Pages 46-49.

Abstract

Epidermolysis bullosa simplex-severe (EBS-severe) caused by KRT5 p.Glu477Lys is a rare and particularly severe subtype associated with high neonatal morbidity and mortality. We report an infant who during the neonatal period required prolonged multidisciplinary intensive care for the management of several complications, including extensive wounds with blood loss leading to secondary anemia, failure to thrive with gastroesophageal reflux, respiratory distress with stridor and a necrotizing soft tissue infection, ultimately requiring surgical debridement and grafting. Pain control proved inadequate despite continuous morphine infusion, leading to initiation of methadone, which provided effective and stable analgesia. This case underscores the severe multisystem morbidity of KRT5 p.Glu477Lys-associated GS-EBS and underscores the role of methadone in effective pain management in critically affected EB neonates.

PMID:
42696396
Bibliographic data and abstract were imported from PubMed on 05 Sep 2026.

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