Authors
Xiaotong Wang, Chunhui Li, Peidong Xin, Meiwei Zhang, Baoyu Huang, Tiantian Chen, Siyi Li, Yijing Han, Lei Wei, Xuekai Zhang, Yaqiong Liu, Chenglong Zhu, Wenjie Xu, Zhiyong Yue, Wenshi Xue, Wenchao Yu, Peng Zhang, Lingling Li, Mengqiang Yuan, Deyang Tian, Jiyan Qi, Qiang Qiu, Kun Wang, Ximing Guo, Chenguang Feng
Published in
Science advances. Volume 12. Issue 36. Pages eaeb8392. Sep 04, 2026. Epub Sep 04, 2026.
Abstract
Gastropod diversification represents one of the most spectacular evolutionary radiations, underpinned by a fundamentally asymmetric body plan and diverse pigmentation patterns. To understand the genetic underpinnings of these cardinal traits, we constructed a chromosome-level genome assembly for the rainbow abalone, Haliotis iris. Integrating comparative genomics, histoembryology, and molecular assays, we identify a conserved regulatory association between the long non-coding RNA lncRNA1 and pitx that is associated with asymmetric mantle development. In H. iris, this association is supported by chromatin-contact evidence and exploratory data suggesting a possible miRNA-associated post-transcriptional component. Furthermore, we identify a wnt-mitf-tyr framework for melanogenesis and show that the mantle is the primary site of melanin synthesis. Concurrently, we identify mantle-enriched prestin genes that are vibration-responsive, consistent with a possible sensory specialization of the mantle. These findings provide molecular insight into asymmetry, pigmentation, and mantle multifunctionality in gastropods.
PMID:
42696593
Bibliographic data and abstract were imported from PubMed on 05 Sep 2026.
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