Authors
Cong Chen, Peiyi He, Yang Liu, Jiahui Ma, Haiying Zhai, Rong Yu
Published in
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. Pages 1-15. Sep 04, 2026. Epub Sep 04, 2026.
Abstract
Depression involves interacting immune, oxidative, metabolic, neuroendocrine and neuroplasticity networks. This review evaluates mechanistic, preclinical, human and translational evidence for resveratrol in depression.
We conducted a structured narrative review of English-language literature to 30 June 2026 using PubMed, Web of Science Core Collection, Scopus and ScienceDirect, supplemented by Google Scholar and citation searching. After duplicate removal, 4,461 records were screened, 142 full texts assessed and 71 publications included.
Antidepressant-like effects were reported across stress, endocrine, developmental, post-stroke, metabolic and gut-inflammatory models, involving SIRT1/AMPK, NF-κB/ NLRP3, Nrf2/HO-1, mitochondrial and ferroptosis pathways,monoaminergic and cAMP/PKA/CREB/BDNF signalling, and gut brain communication. However, many studies used preventive or concurrent dosing, male animals, high doses or non-oral routes. Human studies were few, heterogeneous and mainly non psychiatric, and do not establish efficacy for major depressive disorder. Nanoformulations may improve exposure, but depression specific clinical validation is lacking.
Current evidence does not support resveratrol as monotherapy or an established depression treatment. It is better positioned as a mechanistic probe and hypothesis-generating adjunctive candidate. Future studies should prioritise therapeutic designs, pharmacokinetic monitoring, standardised outcomes and adequately powered adjunctive trials.
PMID:
42696458
Bibliographic data and abstract were imported from PubMed on 05 Sep 2026.
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