Immunohistochemical Expression of Fascin-1 in Colorectal Carcinoma and Its Association with Pathological Grade and Stage.

Authors

Parsa Kainat, Zahid Ali Nohri, Muhammad Rahil Khan, Riyasat Ahmed Memon, Yusra Shafquat, Ikram Din Ujjan

Published in

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. Volume 36. Issue 9. Pages 1145-1150.

Abstract

To evaluate the expression of Fascin-1 in colorectal carcinoma and analyse its association with clinicopathological parameters and pathological stage.
A cross-sectional Study. Place and Duration of the Study: Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan, from July 2022 to June 2023.
Surgical resection specimens of colorectal carcinoma underwent histopathological processing for the preparation of haematoxylin and eosin-stained slides. Immunohistochemical evaluation for the biomarker Fascin-1 was then performed, and its expression was evaluated according to standard criteria.
There was a total of 73 cases of colorectal cancer in this study. The mean age of patients was 44.76 ± 15.83 years (13-75 years). Histopathological subtype adenocarcinoma NOS was the most common finding on microscopic examination. Moderately differentiated tumours were the most frequent finding (63%, n = 46). In this study, most tumours were of the rectosigmoid region (26%, n = 19). Fascin-1 had positive expression in 46.6% (n = 34) cases. In histopathologic subtype, poorly differentiated tumours had a statistically significant expression of Fascin-1 (p = 0.001). ROC curve analysis of the continuous Fascin-1 product score against pathological stage demonstrated excellent predictive performance (AUC = 0.859, p <0.001). Multivariate analysis demonstrated higher expression of Fascin-1 to be a significant predictor of advanced stage (OR = 6.131, 95% CI: 1.197-31.410; p = 0.030). However, lymphovascular invasion (p = 0.082), tumour deposits (p = 0.798), and tumour grade (p = 0.315) did not show a significant association with advanced stage.
Fascin-1 expression is significantly associated with advanced tumour stage in colorectal carcinoma. Independent association of Fascin-1 with staging in multivariate analysis suggests its potential role as a biomarker for tumour progression. Its higher expression in poorly differentiated tumours and signet ring cell carcinoma also supports its role in tumour aggressiveness.
Colorectal neoplasms, Fascin-1, Immunohistochemistry, Neoplasm grading, Neoplasm staging.

PMID:
42698244
Bibliographic data and abstract were imported from PubMed on 05 Sep 2026.

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