The effect of overnight corneal refractive therapy (CRT) lenses on vision and corneal curvature in Chinese myopes: A prospective, multi-Centre study.

Authors

Jun Jiang, José A Vega, Chi Shing Fan, Xiaomei Qu, Lihua Li, Zhikuan Yang, Judy Fang Yiyun, Kelly Voltz

Published in

Contact lens & anterior eye : the journal of the British Contact Lens Association. Volume 49. Issue 6. Pages 102831. Sep 05, 2026. Epub Sep 05, 2026.

Abstract

To evaluate the effects of orthokeratology lenses (Paragon CRT® 100 [CRT 100] and CRT Dual Axis® [CRT-E], Paragon Vision Sciences, a CooperVision company) on vision and corneal curvature in myopic Chinese children and adults.
This was a 12-month, multi-centre, bilateral-dispensing, single-arm clinical trial. Subjects were eligible for enrolment if both eyes had -0.50 to -4.00 DS, up to -1.50 DC, and no corneal abnormality. Uncorrected distance visual acuity (UDVA), manifest refraction spherical equivalent (MRSE), and corneal curvature were assessed at baseline and at follow-up visits after lens-wear periods of 1 day, 1 week, 2 weeks, and 1, 3, 6, 9, and 12 months.
Four sites in China enrolled 254 subjects aged 8 to 43 years (median: 11 years). Data were collected from both eyes of all subjects. Mean UDVA and MRSE were significantly improved compared to baseline values at all follow-up visits (P < 0.05). Mean UDVA improved by 0.44 ± 0.25 logMAR at Day 1 and 0.68 ± 0.20 logMAR at 1 month compared to baseline (0.65 ± 0.27 logMAR). Mean MRSE improved by 1.66 ± 0.92 D at Day 1 and 2.64 ± 0.69 D at 1 month compared to baseline (-2.66 ± 0.94 D). At 1 month, 94% of eyes had UDVA of ≤0.1 logMAR and - 0.50 D < MRSE < +0.50 D (472/502 eyes, 95%CI: 92-96%). Compared to baseline values, mean corneal curvatures (both steep and flat meridians) were significantly flatter at all follow-up visits (P < 0.001), and mean corneal astigmatism was slightly but significantly lower from the 1-week visit onward (P ≤ 0.007). There were no significant ocular adverse events.
The CRT® orthokeratology lenses are able to temporarily flatten the cornea during overnight wear, temporarily correct myopia, and effectively improve UDVA after lens removal in a large proportion of predominantly paediatric Chinese eyes.

PMID:
42700627
Bibliographic data and abstract were imported from PubMed on 06 Sep 2026.

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