Multi-epitope design against emerging nipah virus towards peptide vaccine development.

Authors

Motukuri Naveen Kumar, Dokka Muni Kumar, Bharathi B V N V, Vamseedhar Annam, Aarthi Pradhan, Shaik Rajiya Sulthana, Yashasvi Singam

Published in

Bioinformation. Volume 22. Issue 6. Pages 3786-3798. Epub Jun 30, 2026.

Abstract

The lack of an approved vaccine against Nipah virus (NiV), a highly fatal zoonotic pathogen causing severe neurological and respiratory disease, remains a major global health challenge. Therefore, it is of interest to design a multi-epitope vaccine targeting the NiV phosphoprotein (UniProt ID: Q9IK91). Conserved B-cell, cytotoxic T-lymphocyte (CTL) and helper T-lymphocyte (HTL) epitopes were identified and selected based on antigenicity, immunogenicity and safety. The resulting vaccine construct was evaluated through structural modeling, TLR4 docking, codon optimization and immune simulation analyses. Thus, data shows the favorable stability, strong receptor interaction, efficient expression potential and the ability to elicit robust humoral and cellular immune responses.

PMID:
42701709
Bibliographic data and abstract were imported from PubMed on 06 Sep 2026.

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