Comparative evaluation of hrHPV DNA testing, cervical cytology and histopathology for cervical precancer detection.

Authors

Atul Jain, Mamta Meena, Shiny Vincent, Iqra Sheikh, Surabhi Sharma, Kuldeep Singh, Rajdeep Paul

Published in

Bioinformation. Volume 22. Issue 6. Pages 3395-3399. Epub Jun 30, 2026.

Abstract

Cervical cancer remains a major public health challenge in India, driven primarily by persistent high-risk HPV infection. Hence, this prospective study evaluated hrHPV DNA testing, cervical cytology and co-testing in 400 symptomatic women, using histopathology as the gold standard for CIN2+ detection. HPV DNA testing showed the highest sensitivity (90%) and diagnostic accuracy (63.8%) compared with cytology and co-testing, while ROC analysis confirmed its superior performance (AUC 0.75). HPV16 was the predominant genotype, followed by HPV18, HPV52 and HPV58, together accounting for most high-grade lesions. Thus, we show HPV DNA testing as a more reliable primary screening method than cytology in resource-limited settings.

PMID:
42701751
Bibliographic data and abstract were imported from PubMed on 06 Sep 2026.

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