Authors
Hideyuki Tanaka, Satoshi Nakao, Kana Sugishita, Tomofumi Yamazaki, Seiichiro Ito, Koichi Kageyama, Mugita Sato, Yoko Ino, Kazuhiro Iguchi, Mitsuhiro Nakamura
Published in
Cureus. Volume 18. Issue 8. Pages e114044. Epub Aug 06, 2026.
Abstract
Erythema multiforme (EM) is a rare immune-mediated skin condition often triggered by infections, drugs, or autoimmune diseases. Age-related differences in drug exposure, comorbidities, and biological factors may affect adverse event reporting patterns; however, age-related patterns in EM onset remain unclear. This study investigated age-related patterns in reported time-to-onset of EM.
The observation period was defined as 1-180 days from the initiation of drug administration. Kendall's tau-b rank correlation analysis was used to evaluate the association between ordered age categories and reported time to onset. The Kaplan-Meier method with a log-rank test was used to compare EM onset profiles between two age groups (<60 and ≥60 years).
A positive association was observed between age category and reported time-to-onset (Kendall's tau-b = 0.188, p < 0.001). The median time-to-onset was 10.0 days in both men and women, although the Kaplan-Meier curves differed significantly by sex (log-rank p = 0.012). The median time-to-onset was 8.0 (3.0-13.0) days for those aged <60 years and 12.0 (7.0-24.5) days for those aged ≥60 years (log-rank p < 0.001).
Older age was associated with longer reported time-to-onset of EM, suggesting age-related differences in reported EM onset patterns in a spontaneous reporting database.
PMID:
42701639
Bibliographic data and abstract were imported from PubMed on 06 Sep 2026.
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