Authors
Aurélie Portefaix, Léa Maitre
Published in
Pediatric research. Sep 05, 2026. Epub Sep 05, 2026.
Abstract
Environmental exposures are major determinants of child health, particularly during critical developmental windows extending from preconception through childhood. The exposome framework provides a comprehensive and dynamic approach to studying the totality of environmental exposures and their biological consequences across the life course, moving beyond traditional single-pollutant approaches. Here, we summarize current exposure-assessment tools, including questionnaires, biomarkers, sensors, geospatial indicators, and large-scale databases. It also highlights advances in longitudinal cohort studies, multi-omics integration, and analytical methods designed to address complex exposure mixtures and critical windows of susceptibility. Recent exposome studies have improved our understanding of how chemical, physical, climatic, built-environment, and social exposures interact to influence child health and development. Large exposome cohorts have demonstrated the feasibility of integrating environmental, biological, and social data while identifying pathways linking early-life exposure to child-health outcomes. Ongoing developments in exposure assessment, harmonization, causal inference, and multi-omics integration are accelerating the translation of exposome research into prevention, clinical practice, and public health. Because many environmental determinants of health act during early development, pediatricians should play a central role in translating exposome evidence into prevention, clinical practice, and public-health action. IMPACT QUESTION: WHAT DOES THIS REVIEW ADD TO THE EXISTING LITERATURE?: This review provides a pediatric-focused overview of exposome research, emphasizing critical windows from preconception through early life and their implications for lifelong health It integrates recent advances in exposome assessment, longitudinal cohort studies, multi-omics approaches, and analytical methods, while highlighting current methodological and translational challenges. It highlights the central role of pediatricians in translating exposome research into prevention, clinical practice, and public-health actions by identifying modifiable environmental, biological, and social determinants of child health.
PMID:
42701162
Bibliographic data and abstract were imported from PubMed on 06 Sep 2026.
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