Integrated optic nerve sheath diameter, glasgow coma scale and computed tomography based model for early prediction of clinically significant brain injury in head trauma: A prospective observational study.

Authors

Chandan K Dey, Merin John, Pallavi Shende, Varun Anand, Biraj Majumder, Sudarsan Behera, Ramaswamy N, Klein Dantis, Santosh K Rathia

Published in

Bioinformation. Volume 22. Issue 6. Pages 3762-3767. Epub Jun 30, 2026.

Abstract

Acute head injury requires rapid identification of clinically significant brain injury (CSBI), yet access to CT imaging is often limited, creating challenges in early triage. In this prospective study of 215 head trauma patients, optic nerve sheath diameter (ONSD) and Glasgow Coma Scale (GCS) were evaluated as predictors of CSBI. Patients with CSBI had significantly higher ONSD and lower GCS and both variables independently predicted injury severity. The combined ONSD + GCS model demonstrated better diagnostic performance, clinical utility and calibration than either parameter alone, with ONSD showing a dose-response relationship with CT severity. Thus, data shows the validating a practical bedside risk stratification approach that integrates ultrasound-derived ONSD with GCS to improve CSBI prediction, particularly in resource-limited settings.

PMID:
42701640
Bibliographic data and abstract were imported from PubMed on 06 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.