Ansacarbamitocin B and D isolated from Amycolatopsis sp. FID23-7-18 associated to the fungus-growing ant Mycetomoellerius mikromelanos.

Authors

Brayan Collymore, Yamel Mendoza, Alejandro Almanza, Ricardo Santamaría, Claudia Pérez-González, Nivia Ríos, Laura M Pineda, Michelle G Ng, Carmenza Spadafora, Hermógenes Fernández-Marín, Humberto E Ortega

Published in

Natural product research. Pages 1-13. Sep 06, 2026. Epub Sep 06, 2026.

Abstract

Ansacarbamitocin B (1) and D (2) were identified as major compounds from ISP-2 agar culture of Amycolatopsis sp. FID23-7-18, isolated from the exoskeleton of Mycetomoellerius mikromelanos worker ants. Elucidation of their structures was accomplished using 1D and 2D NMR spectroscopy and MS data. Compounds 1 and 2 showed antifungal activity against the mycoparasite Escovopsis sp. and inhibited the growth of MCF-7, SF-268, and NCI-H460 cancer cell lines with an IC₅₀ of 0.42 to 12.0 µM. Both compounds showed no evident activity against bacteria (Staphylococcus aureus ATCC 25923, Escherichia coli CETC 434, Enterococcus faecalis ATCC 19433, and Pseudomonas aeruginosa ATCC 10145), yeast-like fungus (Candida albicans ATCC10231), and protozoa (Leishmania donovani, Plasmodium falciparum, and Trypanosoma cruzi).

PMID:
42702002
Bibliographic data and abstract were imported from PubMed on 07 Sep 2026.

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