Midbody inheritance predicts re-entry into quiescence, but not lineage potential, in mouse hematopoietic stem cells.

Authors

Tsuyoshi Fukushima, Arne Wehling, Ren Shimamoto, Shuhei Asada, Shunsuke Kawamura, Tomofusa Fukuyama, Susumu Goyama, Timm Schroeder, Toshio Kitamura, Yosuke Tanaka

Published in

Experimental hematology. Pages 105904. Sep 06, 2026. Epub Sep 06, 2026.

Abstract

Hematopoietic stem cells (HSCs) give rise to all blood cell lineages and possess long-term self-renewal potential. HSCs undergo symmetric division for their expansion and asymmetric division to generate one HSC and one progenitor cell which contribute to production of mature blood cells. The midbody is a structure which is formed in the center of the intercellular bridge during cytokinesis. However, the midbody is either asymmetrically inherited by one daughter cell or symmetrically released after cell division, whether these distinct patterns of midbody inheritance influence HSC fate remain poorly understood. In this study, we designed a fusion protein hmKO2 and MgcRacGAP which is a component of midbody. We then traced the midbody inheritance during cell division and the future cell fates of HSC daughters after division by time-lapse imaging. As a result, we found that the midbody release correlated with the delay of the time to the next division but not to the lineage potential of HSCs, indicating the possibility that midbody remnant plays some roles in cell cycle progression.

PMID:
42702233
Bibliographic data and abstract were imported from PubMed on 07 Sep 2026.

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