Near-Field Communication-Enabled Wearable Chemical Sensors for Bioanalytical Monitoring.

Authors

Hang Che, Shiping Gao, Sitong Chen, Jianying Xu, Zhi Dong, Yunyang Bai, Yuqing Lin

Published in

Chemistry, an Asian journal. Volume 21. Issue 17. Pages e70975.

Abstract

This review evaluates the development and analytical potential of near-field communication (NFC)-enabled wearable chemical sensors for bioanalytical monitoring, including passive, battery-free, energy-buffered, and hybrid-energy architectures. Moving beyond conventional wireless data transmission, we emphasize how NFC-based power delivery and smartphone-interfaced readout interact with circuit design, flexible manufacturing, microfluidic biofluid handling, and target-specific interfacial chemistry. Representative applications in sweat, saliva, wound exudate, ocular fluids, and selected body-interfaced or portable point-of-care systems illustrate how sensing performance is governed by interfacial recognition and signal-transduction chemistry, together with sampling fidelity, reader coupling, calibration stability, and validation strategy. Although NFC-enabled sensors have achieved substantial miniaturization and functional integration, important limitations remain, including constrained power transfer, intermittent rather than truly continuous interrogation, calibration drift, biofouling, inter-device and smartphone-dependent variability, and limited real-world or clinical validation. Emerging directions such as hybrid energy harvesting, simplified analog readout, antifouling interfaces, and sensing-intervention integration offer promising opportunities, but their analytical robustness and translational relevance require rigorous assessment. Overall, this Review provides a chemical and analytical framework for evaluating NFC-enabled wearable sensing platforms and highlights the need for standardized validation before biofluid measurements are assigned clinical significance.

PMID:
42702551
Bibliographic data and abstract were imported from PubMed on 07 Sep 2026.

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