Similar Efficacy, Safety, and Immune Improvement Through 96 Weeks in Individuals With Limited HIV-1 Treatment Options Using Twice-Daily Dolutegravir- or Fostemsavir-based Regimens.

Authors

Antonella Castagna, Iacopo Marcon, Fangfang Du, Bo Li, Marcia Wang, Andrew Clark, Cynthia Donovan, Bryn Jones, Manyu Prakash

Published in

Open forum infectious diseases. Volume 13. Issue 9. Pages ofag487. Epub Aug 08, 2026.

Abstract

Constructing suppressive regimens for individuals with multidrug-resistant HIV-1 can be challenging. Separate analyses of 96-week outcomes from the phase 3 VIKING-3 and BRIGHTE studies demonstrate that twice-daily dolutegravir-based and fostemsavir-based regimens each provide robust viral suppression, favorable safety profiles, and CD4+ T-cell count improvement in this population. Clinical trial registration VIKING-3: ClinicalTrials.gov identification number, NCT01328041; URL, https://clinicaltrials.gov/study/NCT01328041; BRIGHTE: ClinicalTrials.gov identification number, NCT02362503; URL, https://clinicaltrials.gov/study/NCT02362503.

PMID:
42703616
Bibliographic data and abstract were imported from PubMed on 07 Sep 2026.

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