Authors
Yan Xu, Lei Shen, Nan Ding, Yaobin Zhu, Yige Chen, Gejingwa Zhao, Zhiqiang Li
Published in
Infection and drug resistance. Volume 19. Pages 623693. Epub Sep 02, 2026.
Abstract
Healthcare associated infection (HAI) in children after open-heart surgery contributes substantially to morbidity and mortality. We aimed to analyze the clinical and microbiological characteristics of HAI after pediatric cardiac surgery.
This single-center retrospective study was conducted in Beijing Children's Hospital from July 1, 2022 to June 30, 2025 including children with congenital heart disease (CHD) who underwent open-heart surgeries.
A total of 1206 patients were included in this study. The overall HAI rate was 13.6%. Multivariate logistic regression analysis found underlying diseases (odds ratio [OR] = 12.342; 95% confidence interval [CI]: 5.744-26.518; P < 0.001), moderate and severe preoperative pulmonary artery hypertension (pre-PAH) (OR = 3.141; 95% CI: 1.311-7.527; P = 0.010 and OR = 3.312; 95% CI: 1.407-7.797, P = 0.006), and aortic cross-clamping (ACC) time (OR = 1.026; 95% CI: 1.008-1.045; P = 0.004) were significantly associated with postoperative HAI. Additionally, no significant association was observed between glucocorticoid use and postoperative HAI in our study. Of the 238 organisms detected, bacteria predominated (55.9%, 133/238). Gram-negative bacilli accounted for 89.5% (119/133) of the bacterial isolates, and Klebsiella pneumoniae was the only multi-drug resistant organism (MDRO) identified.
Our study suggested underlying diseases, moderate and severe pre-PAH, and ACC time were independently associated with postoperative HAI. Klebsiella pneumoniae was the only MDRO among the most common gram-negative bacilli.
PMID:
42703568
Bibliographic data and abstract were imported from PubMed on 07 Sep 2026.
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