Anticancer Potential of Antimicrobial Peptides: Mechanisms, Clinical Application, Challenges, and Future Prospects.

Authors

Qiang Zhang, Shengjun Li, Zhen Wang, Xu Qiu, Xingmiao Yang, Shuai Li, Zheng Gong, Bin Wang, Bei Zhang, Li Zhang

Published in

Drug development research. Volume 87. Issue 6. Pages e70383.

Abstract

Chemotherapy-induced adverse effects and drug resistance remain major obstacles limiting the therapeutic efficacy of cancer treatment, underscoring an urgent need for novel anticancer agents. Among promising candidate molecules, antimicrobial peptides (AMPs) exhibit considerable therapeutic potential owing to their unique mechanisms of action, potent anticancer activity, minimal off-target toxicity, and low propensity to induce drug resistance. In this review, we summarize recent advances in the anticancer properties of AMPs, with a focus on their effects on both cancer cells and immune cells across diverse cancer types, clinical applications, as well as current challenges and future prospects. This review highlights the promise of AMPs as highly effective anticancer candidates for combination cancer therapy.

PMID:
42703893
Bibliographic data and abstract were imported from PubMed on 07 Sep 2026.

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