Identifying therapeutic target genes for acute pancreatitis based on the druggable genes.

Authors

Kejun Cao, Qiang Cheng, Jun Zhu, Bing Wang

Published in

Computer methods in biomechanics and biomedical engineering. Pages 1-14. Sep 07, 2026. Epub Sep 07, 2026.

Abstract

To screen therapeutic target genes for AP, MR analysis was conducted, followed by DEG screening, nomogram, GSEA, drug prediction, and molecular docking analyses.529 druggable genes were obtained. After intersection, 36 overlapping genes were identified. Eight overlapping feature genes were screened after PPI and machine learning. Among them, four therapeutic target genes were screened as therapeutic target genes, containing ACVR1C, RASGRP1, RPTOR, and SPTBN1. These four genes are mainly involved in primary immunodeficiency, and both are negatively associated with activated dendritic cells, neutrophils, and macrophages. Molecular docking analysis highlighted the affinity of the four therapeutic target genes for glucose.

PMID:
42703875
Bibliographic data and abstract were imported from PubMed on 07 Sep 2026.

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