Authors
Jianguo Tao, Dingkun Yao, Mingxin Guo, Jianrui Zhang, Qing Qin
Published in
Small (Weinheim an der Bergstrasse, Germany). Pages e75595. Sep 07, 2026. Epub Sep 07, 2026.
Abstract
Electrocatalytic amide synthesis provides a promising strategy to construct amide bonds from simple carbon- and nitrogen-containing feedstocks under mild conditions. In contrast to conventional amidation, this approach uses electrode potential to regulate substrate activation and C─N bond formation, thereby offering opportunities to reduce reagent consumption and improve process sustainability. However, selective amide formation remains difficult because the target pathway competes with substrate over-oxidation, over-reduction, and the formation of non-amide C─N products. In this Review, we summarize recent advances in the electrocatalytic synthesis of carboxamides from an amide-specific mechanistic perspective. The discussion is organized into anodic oxidative amidation, cathodic reductive amidation, and integrated full-cell electrosynthesis. Particular emphasis is placed on carbonyl-level carbon activation, nitrogen-intermediate generation, interfacial regulation, electrolyte mediation, and reactor configuration. Finally, key mechanistic and engineering challenges are identified to guide the further development of selective, scalable amide electrosynthesis.
PMID:
42703791
Bibliographic data and abstract were imported from PubMed on 07 Sep 2026.
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