8,8″-methylenebis(afzelin): a rare methylene-bridged biflavonoid glycoside from the leaves of Drynaria fortunei.

Authors

Shujin Li, Jiacheng Wang, Xin Chen, Yanyan Liu, Panpan Kong, Yu Peng, Ting Huang, Zixuan Yu, Yongwen Zhang, Rui Tao, Jiqiang Liu, Jicheng Shu, Yonghong Liang

Published in

Natural product research. Pages 1-13. Sep 07, 2026. Epub Sep 07, 2026.

Abstract

Drynaria fortunei is a medicinal fern whose rhizome is traditionally used as 'Gusuibu', whereas its leaves remain underexplored despite their abundant biomass and reported flavonoid richness. In this study, we isolated a novel methylene-bridged biflavonoid glycoside, 8,8″-methylenebis(afzelin) (1), from the leaves of D. fortunei and elucidated its structure by 1D and 2D NMR and HR-ESI-MS. To our knowledge, this is the first methylene-bridged biflavonoid reported from Drynaria and the family Polypodiaceae. DPPH and ABTS radical-scavenging assays indicated that compound 1 showed limited responses under the present conditions, whereas L-ascorbic acid was markedly more potent. These findings expand the structural diversity of flavonoid glycosides reported from D. fortunei and provide a basis for further phytochemical studies and the resource-oriented utilisation of its underexplored leaf biomass.

PMID:
42704319
Bibliographic data and abstract were imported from PubMed on 07 Sep 2026.

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