[Inter-phase hyponatremia ‒ A case report of a three-phase response in antidiuretic hormone release following pituitary surgery].

Authors

María Villaescusa Lage, Jordi Ferri Ciscar, Maitane Hernando Llorens, Alicia Pérez Fuster, Natalia Gutiérrez Mora, María B Toledo Juan, Javier Marín Santonja, María Hermenegildo Zamora, Daniel Polanco Fajardo, Ning Yung Wu Xiong, José T Real Collado

Published in

Nutricion hospitalaria. Sep 02, 2026. Epub Sep 02, 2026.

Abstract

electrolyte disorders are the most common complication following pituitary surgery, with hyponatremia occurring in up to 25 % of cases. The triphasic response of antidiuretic hormone is a rare entity characterized by a sequence of transient vasopressin deficiency secondary to damage of the neurohypophyseal axonal tracts, followed by a phase of syndrome of inappropriate antidiuretic hormone secretion (SIADH) due to the release of preformed vasopressin, and finally by permanent vasopressin deficiency secondary to neuronal gliosis.
we present the case of a 34-year-old woman who underwent pituitary adenoma resection and subsequently developed this complication.
this case highlights the importance of close postoperative monitoring and early treatment to prevent potentially serious complications.

PMID:
42704019
Bibliographic data and abstract were imported from PubMed on 07 Sep 2026.

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