Authors
Pankila Yadav, Palani Selvam Mohanraj, Akash Bansal, Shailendra Dwivedi, Ravi Gupta, Kanishka Kumar, Aroop Mohanty
Published in
The international journal of lower extremity wounds. Pages 15347346261484298. Sep 07, 2026. Epub Sep 07, 2026.
Abstract
AimTo measure serum levels of Pentraxin-3 (PTX-3) and Netrin-1 in diabetic patients with and without foot ulcers and determine how these levels relate to clinical features, glycemic control, and ulcer status.MethodsIn this cross-sectional study, 80 patients were divided into three groups: infected diabetic foot ulcer (IDFU, n = 27), non-infected diabetic foot ulcer (NIDFU, n = 27), and diabetes control (n = 26). Biochemical, demographic, and clinical data were gathered. PTX-3 and Netrin-1 levels in serum were measured using ELISA. ANOVA, regression, and correlation analyses were used to assess biomarker relationships and group comparisons.ResultsAcross all groups, there was a significant increase in fasting blood glucose, HbA1c, and diabetes duration. There was no significant difference in PTX-3 levels. Netrin-1 levels were linked with HbA1c (r = 0.37) and fasting blood glucose (r = 0.41) and were higher in both ulcer groups (p < 0.001). While PTX3 performed poorly (AUC = 0.518-0.576), Netrin-1 exhibited good diagnostic accuracy for differentiating IDFU and NIDFU from DM (AUC = 0.891 and 0.855, respectively). Netrin-1 did not, however, distinguish infected from non-infected ulcers (AUC = 0.510).ConclusionElevated serum Netrin-1 levels and their positive association with glycemic indices suggest a potential role for Netrin-1 in diabetic foot ulceration, whereas PTX-3 showed no significant associations.
PMID:
42704080
Bibliographic data and abstract were imported from PubMed on 07 Sep 2026.
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