Advancements in research on the anti-atherosclerotic effects and mechanisms of traditional Chinese medicine polysaccharides.

Authors

Wen-Rui Tang, Ke Qian Chen

Published in

The Journal of pharmacy and pharmacology. Volume 78. Issue 9. Sep 01, 2026.

Abstract

The purpose of this review is to explore the recent advances in the anti-atherosclerotic effects and mechanisms of traditional Chinese medicine (TCM) polysaccharides.
This review summarizes the extraction, separation, and molecular modification strategies of TCM polysaccharides, and evaluates how different methods affect their structural properties and bioactivities. It also categorizes TCM polysaccharides and elaborates on their respective anti-atherosclerotic mechanisms, while briefly addressing their application prospects in functional foods, biomedicine, and environmental protection.
TCM polysaccharides exhibit broad pharmacological activities, including antiinflammatory, lipid-lowering, immunomodulatory, antioxidant, and gut microbiota-regulating effects, which contribute to their multitarget therapeutic potential against atherosclerosis. Their low toxicity and diverse bioactivities make them promising candidates for prevention and treatment.
Future research should focus on standardization of polysaccharide preparations and clinical trial validation. This review supports the further development of TCM polysaccharides as antiatherosclerotic agents.

PMID:
42704871
Bibliographic data and abstract were imported from PubMed on 08 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.