Recent Exploration of Right-Handed D-Sulfonyl-γ-AApeptides as Potential Tools Toward α-Helical Mimicry.

Authors

Jarais Fontaine, Jianfeng Cai

Published in

ChemPlusChem. Volume 91. Issue 9. Pages e70239.

Abstract

Over the last 15 years, our laboratory has explored peptidomimetics in diverse research areas, including AApeptide folding, structure-based design, combinatorial screening, and supramolecular chemistry. Through these efforts, we successfully introduced a new subclass of AApeptides known as sulfonyl-γ-AApeptides. In recent years, we took advantage of the synthetic scaffold and rationally designed and developed helices targeting a series of protein-protein interactions. This Perspective summarizes our recent advances in developing right-handed helical D-sulfonyl-γ-AApeptides, which closely resemble the secondary structure of canonical α-helices and represent a promising platform for α-helical mimicry.

PMID:
42704836
Bibliographic data and abstract were imported from PubMed on 08 Sep 2026.

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