Authors
M Yan, H Ni, Z Wang, L C Guo
Published in
Zhonghua bing li xue za zhi = Chinese journal of pathology. Volume 55. Issue 9. Pages 795-802. Sep 08, 2026.
Abstract
The pathological diagnosis of B-cell lymphomas is transitioning from traditional morphologic assessment to a multidimensional model that integrates histomorphology, immunophenotype, and genetic alterations. Establishing a standardized, stepwise clinical diagnostic pathway has become an urgent priority in precision medicine. This article systematically delineates a "four-step" integrated diagnostic pathway for B-cell lymphomas: step 1: initial screening and phenotyping, utilizing immunohistochemistry and flow cytometry to determine lineage and establish a preliminary classification; step 2: definitive diagnosis and differential diagnosis, employing gene rearrangement assays and in situ hybridization to verify clonality and identify characteristic genetic abnormalities; step 3: precision diagnostics, applying high-throughput sequencing for molecular subtyping, prognostic stratification, and targeted therapy guidance; and step 4: frontier exploration, leveraging single-cell and spatial multi-omics technologies along with artificial intelligence to address complex diagnostic challenges. It aims to help pathologists develop hierarchically structured and logically consistent molecular diagnostic approaches, promoting the translation of integrated lymphoma diagnosis from theory into clinical practice.
PMID:
42706105
Bibliographic data and abstract were imported from PubMed on 08 Sep 2026.
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