Metabolic signatures in metabolic dysfunction-associated steatotic liver disease-related hepatocellular carcinoma.

Authors

Wen-Jie Fan, Yu-Mei Wu, Xing-Yu Liu, Chen-Ao Zhang, Cui Hu, Bing-Bing Wang, Hao Ding

Published in

Hepatobiliary & pancreatic diseases international : HBPD INT. Aug 27, 2026. Epub Aug 27, 2026.

Abstract

Hepatocellular carcinoma (HCC) is a common and lethal malignancy, with an increasing incidence globally, which is partially attributed to the rising prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD). Complex metabolic rearrangements occur in MASLD-related HCC (MASLD-HCC) to promote the initiation and development of cancer. Nevertheless, comprehensive understanding of the metabolic transformations during the progression from MASLD to HCC remains limited. In this review, we introduce recent advances characterizing the metabolic changes in MASLD-HCC, thereby offering potential directions and clues for further studies.

PMID:
42705966
Bibliographic data and abstract were imported from PubMed on 08 Sep 2026.

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