[Exploration of the mechanisms of portal hypertension driven by metabolic disorders in non-cirrhotic stages of metabolic-associated fatty liver disease].

Authors

Y Q Zhao, Y Wang, J J Liu, H You, J J Zhao

Published in

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. Volume 34. Issue 8. Pages 807-810. Aug 20, 2026.

Abstract

Portal hypertension (PH) is generally considered a complication of advanced liver fibrosis and cirrhosis in chronic liver disease and is closely associated with poor prognosis. Metabolic-associated fatty liver disease (MAFLD) may develop PH even during the non-cirrhotic stages, suggesting that mechanisms beyond cirrhosis exist that contribute to PH. However, prior research has primarily focused on the characteristics and pathophysiological mechanisms of PH in cirrhosis, while systematic discussions on the occurrence of PH in the non-cirrhotic stage of MAFLD are still not expounded. This article takes the metabolic characteristics as an entry point to systematically analyze the roles and mechanisms of the metabolic microenvironment in the development of PH, providing a basis for effectively preventing the progression of PH in MAFLD.

PMID:
42706043
Bibliographic data and abstract were imported from PubMed on 08 Sep 2026.

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