The superior prognostic role of pRB1 over p16 immunohistochemistry as a biomarker in meningiomas.

Authors

Hanna Gött, Jonas Tellermann, Hannes Becker, Christina Fodi, Peter Paßlack, Elgin Hoffmann, Maria Elisa Di Francesco, Daniel J Merk, Jürgen Honegger, Ghazaleh Tabatabai, Marcos Tatagiba, Felix Behling, Jens Schittenhelm

Published in

Acta neuropathologica communications. Volume 14. Issue 1. Sep 03, 2026. Epub Sep 03, 2026.

Abstract

Despite best clinical management, patients with meningiomas frequently experience tumor recurrence. During recent decades, efforts have been made to improve the prognostic stratification of meningiomas by incorporating molecular data. A subgroup of tumors harboring a homozygous CDKN2A deletion was identified, and a higher risk of tumor progression was observed, suggesting the potential use of cyclin-dependent kinases as biomarkers.
In this retrospective single-center study, the immunohistochemical staining for the cyclin-dependent kinases p16, phosphoRB1 (pRB1), CDK4 and CDK6 was analyzed in 1751 paraffin-embedded meningioma samples. For the assessment of p16, CDK4 and CDK6, a semi-quantitative score was applied, whereas an automated quantification tool was used for pRB1. The distribution and association with histopathological results, clinical data and progression-free survival (PFS)-defined by radiographic tumor recurrence-were assessed.
Of all meningioma samples, 14.9% (n = 261) expressed p16. Elevated pRB1 levels were found in 34.5% (n = 589) of tumor samples. CDK4 and CDK6 positive staining was observed in 41.9% and 42.2% of cases, respectively. Dichotomous stratification of meningiomas based on p16 and pRB1 expression levels suggested a significant influence on PFS in univariate analyses. Multivariate analysis determined elevated pRB1 expression, WHO grading, extent of resection, adjuvant radiotherapy, male gender, NF2-status and an elevated MIB1 index as independent prognostic factors.
High expression of pRB1 is an independent prognostic factor for shorter PFS. The prognostic impact of p16 is mostly attributed to the confounding increase of pRB1 expression.

PMID:
42706558
Bibliographic data and abstract were imported from PubMed on 08 Sep 2026.

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