Authors
Hiroshi Yuzawa, Tetsuji Itoh, Thidarut Laochai, Nadnudda Rodthongkum, Hirotomo Nishihara
Published in
Small (Weinheim an der Bergstrasse, Germany). Pages e75692. Sep 08, 2026. Epub Sep 08, 2026.
Abstract
Electrochemical biosensors based on carbon materials have achieved remarkable sensitivity, yet carbon electrodes are still often treated as black-box conductive supports. In this perspective, we redefine carbon materials as hierarchically designable reaction fields in which defect chemistry, edge-site termination, pore architecture, and electron-transport pathways are integrated as explicit design variables, thereby providing a conceptual framework to guide the rational design of biosensor performance. We highlight how emerging analytical tools, including high-temperature-range temperature-programmed desorption and solid-state NMR, enable direct correlation of carbon structure with interfacial functions relevant to molecular recognition, charge storage, and signal transduction. We further discuss recent studies showing that rational control of particle morphology, active-site arrangement, and transparent electrode architectures can improve not only sensitivity but also response stability, signal discrimination, and multimodal readout, highlighting a design direction in which biosensor performance emerges from the integrated engineering of reaction fields rather than isolated material properties. This framework shifts carbon-biosensor development from empirical optimization toward structure-guided design for reproducible and practical sensing in complex samples.
PMID:
42706920
Bibliographic data and abstract were imported from PubMed on 08 Sep 2026.
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