Authors
Luyao Wang, Wen Zhou, Hang Chen, Xiangqian Jia, Peiyuan Zheng, Haolin Jiang, Mengling Wu, Yaning Zhang, Yanchao Ding, Juanjuan Du
Published in
ACS nano. Volume 20. Issue 35. Pages 24401-24414. Sep 08, 2026.
Abstract
Effective lung-targeted therapies can directly treat pulmonary diseases and engage tissue-resident immunity for lasting effects. However, protein delivery systems specifically targeting the lung remain scarce. Here, we report the discovery of phenylborate (PBA)-functionalized polymeric nanocapsules that enable efficient pulmonary delivery of protein cargos following systemic administration. Systematic structure-activity relationship studies revealed that PBA incorporation strongly correlates with enhanced lung tropism, establishing a previously unrecognized materials design principle for lung-targeted protein delivery. Leveraging this capability, we demonstrate that lung-targeted antigen delivery induces robust tissue-resident memory T cell responses within the pulmonary microenvironment and suppresses tumor growth in preclinical models of lung metastasis. Together, these findings redefine the in vivo functional role of phenylborate in nanocarrier systems and establish a versatile materials platform for lung-targeted protein therapeutics and site-specific immune modulation.
PMID:
42708904
Bibliographic data and abstract were imported from PubMed on 08 Sep 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 4
- Comments 0