Total en bloc resection of a giant cell tumour of the cervical spine involving the vertebral artery.

Authors

Koji Uotani, Ying Tan, Aki Yoshida, Haruo Misawa, Tomoko Tetsunaga, Kensuke Shinohara, Yoshiaki Oda, Hisakazu Shitozawa, Masataka Ueda, Ryo Takatori, Toshifumi Ozaki

Published in

BMJ case reports. Volume 19. Issue 9. Sep 08, 2026. Epub Sep 08, 2026.

Abstract

A woman in her 20s presented with neck pain and was diagnosed with a primary giant cell tumour (GCT) involving the C5 vertebral body and encasing the left vertebral artery (VA). Denosumab therapy was initiated to reduce tumour vascularity and facilitate resection. After preoperative embolisation of the left VA, total en bloc resection of the tumour was performed. Postoperatively, the patient experienced transient left upper extremity weakness, which improved significantly over time. Follow-up imaging showed successful bony fusion and no recurrence. This case highlights the importance of multidisciplinary planning in managing cervical spine GCTs involving critical neurovascular structures. Combined denosumab therapy and VA embolisation can enable safe and complete tumour resection, potentially improving outcomes and reducing recurrence risk, especially in young patients.

PMID:
42710959
Bibliographic data and abstract were imported from PubMed on 09 Sep 2026.

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