Melomortsine A - D, unprecedented quinoline alkaloids with anti-breast cancer brain metastasis activity from Melodinus morsei Tsiang.

Authors

Qing Ma, Xiao-Ying Qiu, Zhen-Kun Yang, Rong Zhang, Ying Wang, Qian Feng, Zhong-Qiu Liu, Rong-Rong Zhang

Published in

Phytochemistry. Pages 115079. Sep 08, 2026. Epub Sep 08, 2026.

Abstract

Four unprecedented alkaloids, melomortsines A-D (1-4), and 13 known alkaloids were isolated from Melodinus morsei Tsiang. Melomortsine A, a monoterpenoid quinolone alkaloid, had an unprecedented 6/6/5/5/5 pentacyclic quinolone alkaloid skeleton. Detailed nuclear magnetic resonance spectra analysis, electronic circular dichroism calculations, and X-ray crystallographic analysis were used to elucidate their structures. These compounds could inhibit the pro-inflammatory cytokine and chemokines secretion, and compound 1 exhibited the strongest inhibitory effect. Scandine N₄-oxide (5) significantly inhibited 4T1-BrM by reducing both polymorphonuclear and monocytic myeloid-derived suppressor cells (MDSCs) to remodel immune microenvironment in the brain. Mechanistically, scandine N₄-oxide inhibited the secretion of chemokines by regulating JAK2/STAT3 signaling pathway of M2 type microglial cells, thereby suppressing the recruitment of MDSCs. Overall, scandine N₄-oxide can effectively inhibit the process of BrM in breast cancer, providing a new potential strategy for the therapeutic of breast cancer BrM.

PMID:
42710725
Bibliographic data and abstract were imported from PubMed on 09 Sep 2026.

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